Hand-holding big lenses, BBF is very difficult, especially if you are working at awkward angles (such as from a car). For this reason I use reverse back button focus (RBBF) - set the AF-on button to STOP autofocus. Wouldn't dream of doing it any other way for big lenses.
For my 5D II, which pretty much only ever gets used with a 16-35 and has a hopelessly primitive autofocus system with a tiny spread such that you seldom have an AF point over your area, I need to focus and recompose a lot. On this one I *(do* use BBF (orthodox BBF, not reverse) because there is no issue with handholding such a little lens, and focus-recompose is significantly easier.
When I first tried BBF on the 5D II instead of RBBF, I imagined that it would be very confusing as all my other bodies use RBBF, but to my surprise I discovered that it's quite easy to switch back and forward between the two, and my thumb seldom "forgets" which camera it is using.
On the 7D II, because of all the extra nonsense Canon have added for video shooters, the back of the camera is quite crowded and when hand holding a big lens it is very, very easy indeed to press the AF-on button without meaning to. (The 7D II back is very cramped compared to any of the 5Ds or 1Ds, or the 7D Mark 1.) I nearly sent a brand new 600/4 back for intermittent failure to AF issues until I twigged that it was the location of the AF-on button which was causing problems. (Wouldn't be an issue if I had smaller hands.) So I re-purposed the * button to be the focus lock and disabled the AF-on. Works perfectly.
Kudos to Canon for their excellent control customisation system. It really does make a photographer's life easier.