I’d like to ask if anyone has used both lenses either on an R body or on their respective mounts, and wether, the 400mm focal length not being necessary, the brighter aperture on the EF lens makes it a more compelling choice. Arguments concerning sharpness, autofocus, stabilisation and minimum focusing distance and other factors can be discussed as well.
I’ve used both, but on different cameras, so difficult to compare. I did not find the non-L 70-300 ii very good (on an 80D). To be frank, I found the RF 100-400 a little disappointing, even trying a second copy and borrowing a third. However at its price, for a travel lens, it’s ok. For wildlife or anything critical, it’s not good enough on an R5. It will “seem” better on a 20MP R6. What was wrong? AF was not always consistent, varying between images in a burst. Bokeh is very busy - branches, grasses etc appearing double, so distracting. IS sometimes gets confused, introducing blur where it shouldn’t - better to turn IS off at higher shutter speeds. Aperture absolutely not a problem - R5 or R6 will be fine at higher ISOs.
I know this lens gets a lot of love, but sadly not from me. If you’re happy to adapt EF lenses, do consider the EF 70-300 L which is a bargain on the used market, a much better lens in my opinion, and balances well on a FF R series body with the adapter. Even better, the EF 100-400 L mk ii or the RF 100-500. If you only have one chance for an image (eg on an expensive safari trip), you will regret not having a better lens.