Seems you are away for a while, so let me summarise based on what I think I have understood from you.
Firstly, I am not sure there is evidence that any corruption (i.e. over-writing of data on the magnetic surface of the HDD) is actually taking place. What you do have is LR reporting that it cannot always read the contents of a RAW file that it has previously read off your HDD. You have other applications (OS X Preview) similarly unable to read the data.
As far as I can determine, nothing so far says any data was corrupted (i.e. changed) on the HDD. In fact you have the converse that OS X apparently reports same file date/time for a "corrupted" vs non-corrupted version of a file; that means if anything is corrupting it is a real low-level write operation, beneath the OS. LR definitely does not do that because it can equally work image files on local drives, network drives, USB drives, etc., etc., and I really don't believe LR is stacked full of low-level drivers for every network architecture and storage device it might encounter. In fact I know it uses the OS services because I can trace that on my own MacBook installation of LR4.1 with iosnoop, etc..
So - I would suggest as a theory that your HDD where the images are stored is failing or behaving intermittently on file reads , possibly just on data reads from certain sectors. It's possible a HW failure or miss-connection is inadvertantly writing to the disk during what was supposed to be a read operation, but I would more believe you are actually seeing failing reading. The fact that the corruption is inconsistent (you say the file can look different each time) would again maybe suggest read failure. When you re-copy the non-corrupted file, I think that will write it to new sectors on the disk.
I am presuming your LR catalog, preview files, and camera raw cache are sensibly on your SSD. So LR will often show the correct image from it's own earlier cache or previews. As far as I know LR reads the original RAW when it is selected for edit in Develop Module or during Export. I think in Library module, and at other times it uses the Previews or 1:1 camera RAW cached version.
One way for you to prove this failing HDD theory is to either put the images being worked on onto your SSD, or onto another USB HDD, and just re-observe the behaviour when re-working the images in LR. It is easy to copy the RAW files using the OS into a new folder on a new drive, and then just update the folder location in LR's library module. All LR adjustments to date will be preserved that way because they are in the catalog database.
Provided there is space on the SSD or a convenient USB HDD that would be my next step anyway.
If not I would be checking your HDD connection cables and the physical HDD installation in general.
[ If you still sees RAW corruption on another disk, then that's a deeper case and suspicion could/would swing back to LR, but I just believe there are so many installations of LR in place around the world, even now being used with D800's larger files, that there would be more noise in the Adobe forums and elsewhere about it. ]