There is no best setting, as everyone does things differently.
Me I use P for general capture as the camera can think quicker than me , but if I’ve a certain shot or style in mind I’ll set the camera up to suit that .
Ie that one person who is motionless while others hurry on past I’ll use manual , set a wide aperture, low shutter speed to blur the motion of those in hurry and use auto iso .
If I want to isolate a subject I’ll use aperture priority and a telephoto lens .
I use centre focus point whether or not I’m using AFS or afc but if using afc I’ll use centre with lock on tracking and face/eye detect on and back button af-on