I have an Epson Stylus Photo 2100 that hasn't been used for years. And now I want to try to fire it up. I have some unopened new (NOS) cartridges.
What are your recommendations on "startup procedure"? I am thinking I need to do some kind of thorough cleaning before even trying the printers built in head cleaning.
First, IIRC the 2100 is the same printer that was sold in the U.S. as the 2200, and it uses the very first version of Epson UltraChrome inks. If so, then you may want to skip the effort, or at least much effort, because Epson discontinued the inks years ago, and full Epson ink cartridges are getting hard to find.
If that doesn't deter you, then balance the time and money you spend with the results you might achieve. My
guess is that getting a bunch of refillable cartridges, filling them with Piezo Flush, and then trying to work that through is the process most likely to get good results with little or no risk of damaging the printer. But that's considerable money and effort for a printer for which you can't even buy new Epson ink.
Alternatively, gently shake whatever ink cartridges you have, install them, and print a nozzle check. If you get mostly the correct pattern, try alternating patterns of one or two self-cleanings, waiting several hours, and printing a nozzle check. If several cycles of that get you nowhere, then maybe ask yourself about throwing good time and money after bad.