You are dealing with narrower depth of field and greater resolution. This will be far less forgiving of error.
Your technique will need to be better than ever. Nailing focus, keeping the camera steady.
This have been said a lot of times - I still not quite do agree.
Why is it a given thing, that by having more resolution, you are changing the way, you view an image.
If you always have viewed at 100% - or always have printed at wall sizes, you are right - more resolution will show you smaller details - but my experience is, that this is not the normal way, viewing images are done.
The narrower depth of field (which can be discussed), will not be "less forgiving" because of the format sizes - shoot the two with conditions of same depth of field, and they will be equal "less forgiving".
And be sure to micro adjust your lenses.
Even better - be sure to micro adjust your lenses, if they need to be adjusted
Out of my 10+ lenses, I have only one, that needs adjustments, and I'm still not sure, it's AF Fine tune, it needs - outdoor it's perfect without - indoor it's inconsistent even with.