I have some FW devices that routinely hang the Finder, where routinely means maybe 15% of the time I use them (I use them for one weekly backup, so I see this once every six weeks or so). They are part of a six device chain, with a 'bridge' from FW800 to FW400 between the first two and the other devices. They don't hang the Finder right away but at some point the Finder might stop reacting to commands (they also hang Disk Utility, ie, when I try to start DU while the Finder is already unresponsive, DU becomes unresponsive right after startup as well).It's unfortunate that FW800 was dropped so early by Apple because my experience is that they still don't have their implementation of USB3 nearly as solid, even as late to the party as they brought it. I use USB3 plenty for storage but FW800 is always in line and gets the call for when it has to be bulletproof. Never had a hiccup in FW800 or 400 for that matter.
Thunderbolt is great for sending to many different devices through the same path. It works. But for storage, going directly into an enclosure it makes either no sense or little sense.
USB2 I personally don't have the patience for, especially coming out of a Mac. I used to think, jokingly, that in the old days Apple would make their USB2 ports underperform on purpose so that FW seemed even more of a necessity. The fact that I still can't base a reliable workflow that includes timed backups around USB makes me think it's not such a crazy thought.
I had zero problems with my sole USB 3 device (on a 2012 MBP) but then it's only a 'one-device-chain' and the drive enclosure is fairly new (a Voyage USB 3/eSATA/FW800 dock used with multiple bare drives).
And I had the occasional problems with FW drives all along the last 10+ years with drives not mounting or hanging the Finder. But that might have nothing to do with FW, as I've used only FW drives only very occasionally plugging in one of the drives via USB 2 when I couldn't put it onto the FW chain because the chain wasn't providing enough power (I'm looking at you Voyager FW800 dock) and I've long since lost track of the power supplies of these 2.5" external drives.
One more note, I never sleep my Mac with any drives connected as the backup drives get only connected for backups and TM uses a TC.