hi,
i detect a slight hint of motion blur. In my opinion you could improve the photograph by bumping up the ISO to 800 which will give you a faster shutter speed.
Also, it would be nice if some of the moustache and the hair just above the forhead were in sharp focus along with the eyes, so you might want to set your F-number or aperture accordingly.
Ultimately, its a give and take between shutter speed/depth of field/high ISO noise.
You will have to compromise one of the above factors or resort to using bounced flash.
hope this helps.