Yes, this appears to be an issue with latest version of Lr. I have run into the same problem with the High Resolution images from the s1RII. Lightroom gives the error message about 50% of the time. C1, hav has yet to fail on any of them. I noticed this on the DPreview downloadable test images. They I believe had 2 of them and the one of the temple worked fine, the one with all the pine trees gave the error in Lr. I have not tried Camera Raw/Bridge on any of my High resolution shots as I do not prefer that workflow.
Panasonic just updated the firmware today on the S1RII, 1.2 I have yet to install it. Not sure if it will make any difference as the issue is clearly an Adobe issue with the make up of the files.
It's may assumption that Adobe Camera Raw is seeing some of the slight misaligned parts on some of the High resolution images and is erroring out.
The overall impression I have is that the Mode 2 works pretty good with a slight breeze, and and the High resolution images appear to work better in the lower ISO ranges. Much past 800 and I see some problems.
You may also note that on the High resolution, the Lr/Camera Raw Denoise will give some very harsh results. Basically can't be used.
Still not anywhere near a perfect solution, and this IMO is where an AI driven solution makes sense, although it would take a lot of processing to work.
Taking the 178MP output down to around 100MP, can give some very nice images which still have plenty of resolution for a large print.
Paul