For A3 prints, clean ISO6400 is more important than astronomic sharpness.
Clients are not really interesting in seeing tiny skin pores.
But a noise-free low light no flash portrait is what many wedding and performance photographers are after.
...of assuming that more pixels is at odds with cleaner photos. Let's say we have two sensors with the same efficiency (same QE and same read noise / area). One sensor is 10 MP, the other is 40 MP.
We take a pic of the same scene with the same settings. Let's say, f/2.8 1/100 ISO 6400.
Now, at 100% view, some will say that the 40 MP photo is more noisy. Others will say the 10 MP photo is more blurry:
http://forums.dpreview.com/forums/read.asp?forum=1018&message=35068712
Either way, this is because at 100% view, you are viewing the scene from the 40 MP sensor with double the enlargement as from the 10 MP sensor.
There are a couple of things we can do. We can just print the photos. If the person vewing the photo is unable to resolve the higher detail of the 40 MP photo (due to viewing distance, print size, visual acuity, paper, etc.), then the 40 MP photo won't look any more noisy.
If, however, they can see the extra detail from the 40 MP photo, and they would prefer a cleaner photo to a more detailed photo, we could simply apply NR (noise reduction) to the 40 MP photo, and create a photo that has the same detail as the 10 MP photo, but with
less noise.
In other words, more pixels simply give you more IQ
options than fewer pixels for equally efficient sensors.
Nor are sensors with larger pixels necessarily more efficient. The Canon G12 has larger pixels than the Canon G10, and the G12 sensor is more efficient. However, the Canon 5D2 has smaller pixels than the Canon 5D, but the 5D2 sensor is more efficient.
In both cases, it's the newer generation sensor that is more efficient, more pixels or not. So, the more pixels you can put on the sensor, the better, in terms of IQ.