Great security guard, nothing phones home without permission, foils any spyware that one might inadvertently and foolishly install. It's also very lightweight so there's no hit to system resources. It's the only anti-malware app I've ever used or felt the potential need for. For those interested:
http://www.obdev.at/products/littlesnitch/index.html
http://www.obdev.at/products/littlesnitch/index.html
I use Hands Off to monitor outgoing network connections; a similar program is LittleSnitch. These types of programs will alert you if you inadvertently install a Trojan Horse that attempts to "phone home."
I also use Witopia's personalVPN service to secure data transfers at wireless/wired hotspots and to hide my IP Address online.
Anti-virus software on a Mac? Fergit About It!