Unfortunately that is not the case, the noise creates bands and patters that hold up after resizing and while some noise reduction programs help, they don't do so nearly enough. Furthermore the CCDs used in medium format digitals drastically loose dynamic range as the sensitivity is increase. Color rendition also drops at high ISO as a result. There has been a lot more market in the 35mm DSLR market so there has been a lot more R&D there, the sensors are a lot better. At 1600 ISO, 400 ISO film pushed two stops holds up a lot better than medium format digital.I shot a lot of low light stuff with both those cameras, FWIW. Still do with the 645NII. The negative is so big that even though there's noise (grain) it's not too objectionable. I tend to imagine that the same would hold true with the S2. It's nearly 40 megapixels. Scale the image down to 20 and I tend to imagine that the noise will pretty much be in line with the noise from a 20-megapixel DSLR.
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~Kurt