Looks amazing! What are the different drawbacks of reversing a
lens like that? Manual focus I know, but what about everything
else? What's the focus distance and such like???
The focus distance is fixed at 44 mm based on the EOS lens mount clearance. The depth of field is
extremely small and you have to have everything motionless, rigidly mounted, and use a remote and mirror lockup to get clear images.
I'd love to use my Canon EF 28-300mm f/3.5-5.6L IS USM lens (77mm
filter size) with the kit lens reversed, EFS 18-55mm (58mm size).
You could do this with two step-down rings (77-62 + 62-58) plus one 58-58 macro coupler. Before you buy those though, you can do a quick test just putting the lenses together with masking tape and see if the image looks promising. I have that 18-55 kit lens and I'm not super impressed with it, I would suggest the 50/1.8 prime instead.
On the 8 Mpixel 1.6 crop factor cameras like my 20D, about 6x macro is really plenty. That's because the pixel size is 6.4 microns. With a 6x lens that would be one pixel per micron of your subject. That is roughly the size of two wavelengths of green light. Even with perfect lenses, perfect focus, no subject motion, etc. the image will start being blurred by diffraction if you try much more magnification. So beyond about 6x, increasing the mag. just reduces your field of view without giving you appreciably more detail.
Even 6x requires extreme care. I tried an image of a penny, and the date "2006" filled the field of view. The surface of the penny was more or less in focus, but the raised edges of the letters were clearly not in focus... I think that's less than the thickness of a piece of paper.