Coming from the fully manual Canon F-1 and my 1970 Leica rangefinder the 5D and previously the 20D have taken me a while to get comfortable with. And they aren't as user friendly when you want to use them in full manual mode as the older cameras were.
But I'm now finding it pretty quick to work with the camera all manual. I keep in in spot meter mode. I set all my lenses to autofocus. But I also set custom function 04 to option 1, so the camera only autofocuses when I press the * button with my thumb. For the most part I focus manually, but it's nice to have that autofocus available on occasions. This only works with USM lenses by the way. I set it so that only the central AF point is active.
In terms of user friendliness it's no F-1, but it's pretty close. And of course it does one or two things the F-1 dreamed of. ;-)
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Peter White