Interploation is a tool, and we all use it occasionally, but it is
no subsitute for the real thing.
I just produced two large prints for a client at 39" x 59" using
RAW files from a 1ds. One was a straightforward interpolated
enlargement. It looked pretty good, but was far from perfect. The
other was a stitched image, and that WAS perfect.
Even A4 prints for magazines are very noticable weather you have
used something like a 1ds / MF as opposed to a 6mp camera
interpolated. We know because we produced one issue with photos
from half and half as we changed over our camera equipment.
Those interpolated imaged looked embarrasing against the
uninterpolated 1ds images.