Trying something with another person's file is one thing, but I find the best way to know if a tool works for you is to try it on your files.
DXO offers a 30 day trial, so I downloaded a copy and tried it on some files.
Short version:
For the files I tried, with the lenses I used on my GFX 50R, both programs did a great job. However, (1) I can't get the full benefit of DXO's sharpening tools because my lenses are not profiled; and, (2) there's something happening on the noise front when the DNG produced by DXO comes into Lightroom.
Long version:
The first thing I discovered right out the gate is that the Lens Sharpness tool is only available if your lens is in DXO's database. Not a single lens I use is in DXO's database. Your only option in that case is to rely on DXO's sharpening tools.
Mads: I was trying to duplicate your settings exactly, so I couldn't do that. Keep that in mind when you look at these samples.
I ended up exporting the file I was trying it on two ways: with Unsharp Mask off (and then sharpening in Lightroom), and with Unsharp Mask on (using the default settings, and then no sharpening in Lightroom). I used all the other settings you specified except vignette.
Here I'm only showing the "sharpened in LR" version because the ones that came out of DXO with the default sharpening were not good. I'm sure someone who knows how to use DXO better than I do could get better results.
The test files I used for this exercise were made with a new lens: an SMC Pentax 67 200mm f/4 with the 1.4x teleconverter, so effective focal length of 280mm. To make this a more realistic test for me, I worked on an f/11 file (an aperture I use a lot), and an f/22 file (an aperture I normally never use because it's crap, but I was curious).
Here's a long view down a street at f/11 on a hazy day. Lightroom is on the left, and DXO on the right. There are some differences, but to my eye, both programs do a great job. Keep in mind that whatever secret sauce DXO might have applied had I used a profiled lens is not being applied here.
Pentax 67 200mm f/4 with the 1.4x teleconverter -- so 280mm at f/11. 200% magnification
Every new lens that comes into my hands ends up in my kitchen sooner or later. There's lots of light, and different kinds of surfaces and shapes. This is a knob on my toaster oven at f/22.
I don't know about you, but this should look like crap -- a soft mess due to diffraction. I'm astonished by how good this lens is. Remember, this is a decades old film-era telephoto lens with a teleconverter at f/22. Amazing.
Both tools do a great job as far as I'm concerned. They both pulled out the circular striations in the knob and the brushed texture of the steel. I was not expecting to see that.
Pentax 67 200mm f/4 with the 1.4x teleconverter -- so 280mm at f/22 if you can believe it. 400% magnification
Here's the more interesting result. Both images are in Lightroom, and noise reduction is off. The only difference is that the one on the right came out of DXO with Deep Prime noise reduction.
Importantly, inside DXO it doesn't look that bad. Is something happening to the file once it comes into Lightroom that makes it look like this?
Comparing noise treatment in an area of smooth texture. Magnification is 400% in this screenshot
Did I see anything in DXO that would make me want to use it to develop my RAFs? No, I did not. However, it does a great job, and maybe with profiled lenses it would pull ahead of Lightroom. But for someone like me, Lightroom is still the tool of choice.
Mads, thanks again for starting this thread. Benchmarking our tools and techniques every once in a while is incredibly valuable. You helped me do that.