What is the limitation with medium format?

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MinAZ
MinAZ Senior Member • Posts: 4,186
What is the limitation with medium format?
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I've heard at a few times people refer to the inherent limitations of medium format, trading stuff like AF speed for IQ (see here for example: https://petapixel.com/2018/09/18/was-the-fujifilm-gfx-a-mistake-should-fuji-have-gone-full-frame-instead/

But just what is the limitation? Why can't a MF camera focus as fast as a FF camera? What are the inherent limitation of MF that makes FF so popular (other than the obvious size and cost)?

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