Zoom/Focus rotation direction - Does it matter to you?

Yes, I do have a focusing ring preference, and it is the way Nikon lenses manually focus. My zoom preference is less-established, perhaps because I did not seriously use zooms for fast shooting of active subjects until somewhat recently. If I am able to "warm-up" a bit, with a lens, however, zooming and focusing direction has not been problematic, though it is, probably, ideal for me to use Nikon if I think manual focus has to be done with any urgency.

My main use of manual focus with Canon cameras has been with macro and near-macro subjects, which is not normally done in a hurry, so the difference in in focus-ring direction has been a very minor annoyance.

My first several DSLR cameras were Canon, but I first started learning DSLR operation with a then-new Nikon D300s, issued to my wife by her employer, so Nikon pro/semi-pro bodies have felt "natural" to me since then. I bought a Novoflex EOS/NIK adapter relatively early during my learning process, and Nikon manual-focus lenses, so that we could share the lenses on our differing brands of cameras, so I became accustomed to Nikons' focusing ring direction. I really do like some of the AI-S Nikkors.

As for zoom ring direction, I am more accustomed to Canon, at this point, because I used Canon zooms as early as 2010, and did not use a Nikkor with a zoom ring very much until May 2015, when I bought a 14-24/2.8G, soon followed by a 24-70/2.8G. (I did use push-pull-zooming Nikkors as early as 2011.) I may well develop a conditioned preference, however, for Nikon zoom rings, as I often use my 24-70/2.8G for active subjects, whereas I tend to use my Canon zooms for static subjects.

On a technical note, I seem to recall that some past Nikon-branded lenses have zoom rings that operate in the "wrong" direction. I am not certain of this, but seem to recall reading about it.

I do not think it is excessively "OCD" to have a strong preference for a particular lens focusing and zooming system. It probably matters more for action and event shooting, of course. and much less for static subjects.

Notably, Zeiss ZF and ZE lenses, if I remember correctly, focus in the "correct" direction for each mount.