My typical kit is a 16-28 Tokina, 35 F2 Zeiss, and Nikon 85 F1.4. I use the Domke F2.
Also carry a couple of SB-800's.
The bag is basically divided in two, one area has a pouch that has adjustable dividers for your lenses, the other is open and where you would typically place the camera. Plenty of pockets for other items as you choose.
I have tried other shoulder bags but I keep coming back to this.