I have used the 300mm AF (not AFS) F/4, with the tc-200. You definitly need a tripod and mirror lock up, and remote release. The results are what you would expect, slightly soft, but with some post processing, the results are pretty good. I use a D800 and I plan on shooting from the same position, using the TC-200 and then shooting without the converter. Then cropping the no converter shot to duplicating the converter image and then comparing the quality. I have a feeling that the cropped image would be better. You can crop a D800 shot alot. When I learn how to upload images, I will.