Lightroom Plug in for fixing OOF images.
The best software application I have found is Topaz Labs Infocus program. It runs as a plugin with Photoshop or can be run standalone with the free Topaz Fusion Express software. What is different about Infocus is that is provides control over "focus" and also provides for micro contrast adjustment (like Clarity when doing RAW conversions).
Often contrast is a problem in the areas that appear OOF and the micro contrast adjustment is a good place to start. It also minimizes the amount of sharpening needed much of the time.